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lüll Role of synaptotagmin in Ca2+-triggered exocytosis Tucker WC; Chapman ERBiochem J 2002[Aug]; 366 (Pt 1): 1-13The Ca(2+)-binding synaptic-vesicle protein synaptotagmin I has attracted considerable interest as a potential Ca(2+) sensor that regulates exocytosis from neurons and neuroendocrine cells. Recent studies have shed new light on the structure, biochemical/biophysical properties and function of synaptotagmin, and the emerging view is that it plays an important role in both exocytosis and endocytosis. At least a dozen additional isoforms exist, some of which are expressed outside of the nervous system, suggesting that synaptotagmins might regulate membrane traffic in a variety of cell types. Here we provide an overview of the members of this gene family, with particular emphasis on the question of whether and how synaptotagmin I functions during the final stages of membrane fusion: does it regulate the Ca(2+)-triggered opening and dilation of fusion pores?|*Calcium-Binding Proteins[MESH]|*Vesicular Transport Proteins[MESH]|Animals[MESH]|Calcium/*metabolism[MESH]|Cell Membrane/metabolism[MESH]|Endocytosis[MESH]|Exocytosis[MESH]|Humans[MESH]|Kinetics[MESH]|Membrane Fusion[MESH]|Membrane Glycoproteins/*chemistry/*physiology[MESH]|Membrane Proteins/metabolism[MESH]|Models, Biological[MESH]|Nerve Tissue Proteins/*chemistry/*physiology[MESH]|Nervous System/metabolism[MESH]|Protein Isoforms[MESH]|Protein Structure, Tertiary[MESH]|SNARE Proteins[MESH]|Synaptotagmin I[MESH]|Synaptotagmins[MESH] |