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Transcription factor fusions in acute leukemia: variations on a theme Scandura JM; Boccuni P; Cammenga J; Nimer SDOncogene 2002[May]; 21 (21): 3422-44The leukemia-associated fusion proteins share several structural or functional similarities, suggesting that they may impart a leukemic phenotype through common modes of transcriptional dysregulation. The fusion proteins generated by these translocations usually contain a DNA-binding domain, domains responsible for homo- or hetero-dimerization, and domains that interact with proteins involved in chromatin remodeling (e.g., co-repressor molecules or co-activator molecules). It is these shared features that constitute the 'variations on the theme' that underling the aberrant growth and differentiation that is the hallmark of acute leukemia cells.|Animals[MESH]|Apoptosis[MESH]|Cell Cycle[MESH]|Cell Differentiation[MESH]|Cell Division[MESH]|Humans[MESH]|Leukemia, Myeloid, Acute/*metabolism[MESH]|Mice[MESH]|Models, Biological[MESH]|Nuclear Pore Complex Proteins/chemistry[MESH]|Oncogene Proteins, Fusion/*chemistry/*metabolism[MESH]|Receptors, Retinoic Acid/chemistry[MESH]|Retinoic Acid Receptor alpha[MESH]|Transcription Factors/*metabolism[MESH] |
