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lüll NFAT signaling: choreographing the social lives of cells Crabtree GR; Olson ENCell 2002[Apr]; 109 Suppl (ä): S67-79Calcium signaling activates the phosphatase calcineurin and induces movement of NFATc proteins into the nucleus, where they cooperate with other proteins to form complexes on DNA. Nuclear import is opposed by kinases such as GSK3, thereby rendering transcription continuously responsive to receptor occupancy. Disruptions of the genes involved in NFAT signaling are implicating this pathway as a regulator of developmental cell-cell interactions.|*Nuclear Proteins[MESH]|*Signal Transduction[MESH]|Active Transport, Cell Nucleus[MESH]|Animals[MESH]|Calcineurin/metabolism[MESH]|Calcium Channels/metabolism[MESH]|Calcium Signaling[MESH]|Cardiovascular System/cytology/growth & development/metabolism[MESH]|DNA-Binding Proteins/*metabolism[MESH]|Feedback, Physiological[MESH]|Humans[MESH]|Lymphocytes/cytology/immunology[MESH]|Macromolecular Substances[MESH]|Musculoskeletal Development[MESH]|Musculoskeletal System/cytology/metabolism[MESH]|NFATC Transcription Factors[MESH]|Transcription Factors/*metabolism[MESH] |