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lüll Live and let die: Nef functions beyond HIV replication Fackler OT; Baur ASImmunity 2002[Apr]; 16 (4): 493-7The viral Nef protein is important for the progression of the human and simian immunodeficiency virus (HIV/SIV) infection. So far, experimental evidence has suggested that Nef enhances viral replication and infectivity through a combination of different effects. Recent insights, however, indicate that its functions are more complex than previously anticipated. By targeting the T cell receptor, Nef may not only prime viral replication but, more importantly, ensure viral survival through distinct mechanisms of immune evasion and antiapoptosis.|Animals[MESH]|Apoptosis/immunology[MESH]|Gene Products, nef/*immunology[MESH]|HIV/*immunology/physiology[MESH]|Humans[MESH]|Receptors, Antigen, T-Cell/immunology[MESH]|T-Lymphocytes/immunology/virology[MESH]|Virus Replication/*immunology[MESH]|nef Gene Products, Human Immunodeficiency Virus[MESH] |