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  • Viral and cellular interleukin-10 (IL-10)-related cytokines: from structures to functions
  • Dumoutier L; Renauld JC
  • Eur Cytokine Netw 2002[Jan]; 13 (1): 5-15
  • The anti-inflammatory and immunosuppressive activities of IL-10 have been extensively studied during the last 10 years. More recently a series of new cytokines, structurally related to IL-10, were described. This family includes mda-7, IL-19, IL-20, IL-TIF/IL-22, and AK155. Most of the biological functions of these cytokines remain to be unraveled but new data are coming out steadily. Although none of these "IL-10 homologs" mimics IL-10 activities, they are likely to be involved in inflammatory processes as well. mda-7, IL-19 and IL-20 form a subfamily within IL-10 homologs, based on conserved amino acid sequences, and on the use of shared receptor complexes. Functional studies have stressed the potential suppressing activity of mda-7 on tumor growth. As for IL-20, its overexpression in transgenic mice led to skin abnormalities, reminiscent of psoriatic lesions in humans. IL-TIF/IL-22 is a Th1 cytokine, and was shown to upregulate the acute phase reactant production by liver cells. Finally, for AK155, originally described as a gene induced upon T cell transformation by Herpes-virus saimiri, functional data are still lacking to determine its biological activities.
  • |Animals[MESH]
  • |Cytokines/*chemistry/physiology[MESH]
  • |Genes, Tumor Suppressor[MESH]
  • |Humans[MESH]
  • |Interleukin-10/*chemistry/physiology[MESH]
  • |Interleukins/*chemistry/physiology[MESH]
  • |Mammals[MESH]
  • |Receptors, Interleukin/metabolism[MESH]
  • |Signal Transduction/physiology[MESH]
  • |Viruses/chemistry[MESH]

  • *{{pmid11956016}}
    *<b>[ Viral and cellular interleukin-10 (IL-10)-related cytokines: from structures to functions ]</b> Eur Cytokine Netw 2002; 13(1) ; 5-15 Dumoutier L; Renauld JC


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    Eur Cytokine Netw

    5 1.13 2002