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lüll Vinexin, CAP/ponsin, ArgBP2: a novel adaptor protein family regulating cytoskeletal organization and signal transduction Kioka N; Ueda K; Amachi TCell Struct Funct 2002[Feb]; 27 (1): 1-7Adaptor proteins, composed of two or more protein-protein interacting modules without enzymatic activity, regulate various cellular functions. Vinexin, CAP/ponsin, and ArgBP2 constitute a novel adaptor protein family. They have a novel conserved region homologous to the active peptide sorbin, as well as three SH3 (src homology 3) domains. A number of proteins binding to this adaptor family have been identified. There is accumulating evidence that this protein family regulates cell adhesion, cytoskeletal organization, and growth factor signaling. This review will summarize the structure and the function of proteins in this family.|*Adaptor Proteins, Signal Transducing[MESH]|Animals[MESH]|Cell Adhesion/physiology[MESH]|Cytoskeleton/metabolism/*physiology[MESH]|Glucose Transporter Type 4[MESH]|Growth Substances/metabolism[MESH]|Homeodomain Proteins/*metabolism[MESH]|Humans[MESH]|Insulin/metabolism[MESH]|Microfilament Proteins/metabolism[MESH]|Monosaccharide Transport Proteins/metabolism[MESH]|Muscle Proteins/chemistry/*metabolism[MESH]|Protein Transport[MESH]|Proteins/*metabolism[MESH]|RNA-Binding Proteins[MESH]|Signal Transduction/*physiology[MESH]|src Homology Domains[MESH] |