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Autoimmune hemolytic anemia Gehrs BC; Friedberg RCAm J Hematol 2002[Apr]; 69 (4): 258-71Red blood cell (RBC) autoantibodies are a relatively uncommon cause of anemia. However, autoimmune hemolytic anemia (AIHA) must be considered in the differential diagnosis of hemolytic anemias, especially if the patient has a concomitant lymphoproliferative disorder, autoimmune disease, or viral or mycoplasmal infection. Classifications of AIHA include warm AIHA, cold agglutinin syndrome, paroxysmal cold hemoglobinuria, mixed-type AIHA, and drug-induced AIHA. Characteristics of the autoantibodies are responsible for the various clinical entities. As a result, diagnosis is based on the clinical presentation and a serologic work-up. For each classification of AIHA, this review discusses the demographics, etiology, clinical presentation, laboratory evaluation, and treatment options.|*Anemia, Hemolytic, Autoimmune/classification/diagnosis/epidemiology/etiology[MESH]|Autoantibodies/immunology[MESH]|Cold Temperature[MESH]|Erythrocytes/immunology[MESH]|Hemoglobinuria, Paroxysmal[MESH]|Hot Temperature[MESH]|Humans[MESH] |
