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  • Chemical exposure during pregnancy and oral clefts in newborns
  • Leite IC; Paumgartten FJ; Koifman S
  • Cad Saude Publica 2002[Jan]; 18 (1): 17-31
  • This article presents a literature review on the risk factors for oral clefts (lip and/or palate), emphasizing discussion of maternal exposure to endocrine disruptors. Several studies have identified the risk of cigarette smoking and alcohol consumption, use of anticonvulsant drugs, and exposure to organic solvents. A protective effect has been shown for supplementation with folic acid. As with other chemicals, the risk associated with exposure to sex hormones is still obscure, although some authors describe a moderate risk level. New studies addressing this hypothesis need to be conducted, while the population exposed to these endocrine disrupters is increasing.
  • |Alcohol Drinking/adverse effects[MESH]
  • |Cleft Lip/*chemically induced[MESH]
  • |Cleft Palate/*chemically induced[MESH]
  • |Environmental Exposure/adverse effects[MESH]
  • |Female[MESH]
  • |Gonadal Steroid Hormones/adverse effects/therapeutic use[MESH]
  • |Humans[MESH]
  • |Infant, Newborn[MESH]
  • |Occupational Exposure/adverse effects[MESH]
  • |Pregnancy[MESH]
  • |Risk Factors[MESH]
  • |Smoking/adverse effects[MESH]

  • *{{pmid11910421}}
    *<b>[ Chemical exposure during pregnancy and oral clefts in newborns ]</b> Cad Saude Publica 2002; 18(1) ; 17-31 Leite IC; Paumgartten FJ; Koifman S


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    Cad Saude Publica

    17 1.18 2002