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Gene-specific regulation by general translation factors Dever TECell 2002[Feb]; 108 (4): 545-56Protein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, processing, or export. Recent studies have enhanced our understanding of the translation initiation process and helped elucidate how modifications of the general translational machinery regulate gene-specific protein production.|*DNA-Binding Proteins[MESH]|*Gene Expression Regulation[MESH]|*Saccharomyces cerevisiae Proteins[MESH]|Activating Transcription Factor 4[MESH]|Fungal Proteins/genetics/metabolism[MESH]|Macromolecular Substances[MESH]|Models, Biological[MESH]|Open Reading Frames[MESH]|Peptide Initiation Factors/metabolism[MESH]|Phosphorylation[MESH]|Protein Biosynthesis/*physiology[MESH]|Protein Kinases/genetics/metabolism[MESH]|RNA, Messenger/genetics/*metabolism[MESH]|Trans-Activators/metabolism[MESH]|Transcription Factors/genetics/metabolism[MESH] |
