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lüll A conserved mRNA export machinery coupled to pre-mRNA splicing Reed R; Hurt ECell 2002[Feb]; 108 (4): 523-31Recent advances have led to a new understanding of how mRNAs are exported from the nucleus to the cytoplasm. This process requires a heterodimeric mRNA export receptor that is part of an elaborate machinery conserved from yeast to humans. Export of mRNAs is coupled to upstream steps in gene expression, such as pre-mRNA splicing, and to downstream events, including nonsense-mediated decay.|*RNA Splicing[MESH]|Active Transport, Cell Nucleus/*physiology[MESH]|Animals[MESH]|Fungal Proteins/metabolism[MESH]|Heterogeneous-Nuclear Ribonucleoproteins[MESH]|Humans[MESH]|Models, Biological[MESH]|Nuclear Proteins/*metabolism[MESH]|RNA Precursors/*metabolism[MESH]|RNA, Messenger/*metabolism[MESH]|RNA-Binding Proteins/*metabolism[MESH]|Ribonucleoproteins/metabolism[MESH]|Spliceosomes/metabolism[MESH] |