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lüll Pharmacology and toxicology of astrocyte-neuron glutamate transport and cycling Sonnewald U; Qu H; Aschner MJ Pharmacol Exp Ther 2002[Apr]; 301 (1): 1-6The interaction between astrocytes and neurons is examined from the standpoint of glutamate neurotoxicity. The review details 1. the distribution of glutamate transporters on astrocytes and neurons, provoking a reformulation of the interdependence between these two cell types in removing extracellular glutamate and preventing excitotoxic injury; 2. the potential involvement of aberrant glutamate transporter function in the etiology of neuropathological conditions; 3. the role of astrocyte-neuron interaction in widely divergent aspects of brain energetics; 4. the role of astrocytes in the process of glutamate recycling within the context of anesthetic treatment with pentobarbital and thiopental.|Amino Acid Transport System X-AG/metabolism[MESH]|Animals[MESH]|Astrocytes/drug effects/*metabolism[MESH]|Biological Transport, Active/drug effects[MESH]|GABA Modulators/pharmacology[MESH]|Glucose/metabolism[MESH]|Glutamic Acid/*metabolism[MESH]|Humans[MESH]|Neurons/drug effects/*metabolism[MESH]|Thiopental/pharmacology[MESH] |