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lüll Antineutrophil cytoplasmic autoantibody in the absence of Wegener s granulomatosis or microscopic polyangiitis: implications for the surgical pathologist Gal AA; Velasquez AMod Pathol 2002[Mar]; 15 (3): 197-204Antineutrophil cytoplasmic antibodies (ANCA) are useful serologic markers for the diagnosis and management of patients with Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA). However, problems in diagnosis and classification may occur when patients with other disorders develop ANCA. A 7-year review (1993-1999) disclosed 247 patients whose sera tested positively for ANCA by an indirect immunofluorescence method: 166 patients for cytoplasmic-ANCA (C-ANCA) and 81 patients for perinuclear-ANCA (P-ANCA) Twenty-seven patients had active pulmonary disease and underwent open-lung biopsy or transbronchial biopsy. Eight patients (30%) had a disease other than WG or MPA, and their clinical, pathological, and serological findings were reviewed. The patients, all women, ranged in age from 28 to 77 years (median, 37 y). Dyspnea (n = 6), cough (n = 6), chest pain (n = 2), and/or hemoptysis (n = 2) were present. The duration of symptoms lasted from 3 weeks to 6 years (median, 6 mo). ANCA titers were C-ANCA (n = 4; range, 1:40-1280) or P-ANCA (n = 4; range, 1:40-640). The lung biopsies disclosed nonspecific interstitial pneumonia (n = 4), bronchiolitis obliterans organizing pneumonia (n = 1), diffuse alveolar damage (n = 1), organizing diffuse alveolar hemorrhage without capillaritis (n = 1), and necrotic granuloma (n = 1). No cases showed characteristic histology for WG or MPA. The final diagnoses were various connective tissue disorders (n = 5), chronic hypersensitivity pneumonia (n = 1), postinfectious bronchitis/bronchiectasis (n = 1), and ulcerative colitis-related lung disease (n = 1). Surgical pathologists should be aware that significantly elevated ANCA titers may be associated with diverse forms of pulmonary disease. ANCA positivity alone, in the absence of appropriate clinical or pathologic findings, should not be used to substantiate a diagnosis of WG or MPA.|Adult[MESH]|Aged[MESH]|Antibodies, Antineutrophil Cytoplasmic/*blood[MESH]|Biomarkers/analysis[MESH]|Biopsy[MESH]|Capillaries/pathology[MESH]|Connective Tissue Diseases/immunology/pathology[MESH]|Diagnostic Errors/*prevention & control[MESH]|Female[MESH]|Fluorescent Antibody Technique, Indirect[MESH]|Granulomatosis with Polyangiitis/*immunology/*pathology[MESH]|Humans[MESH]|Lung Diseases/immunology/pathology[MESH]|Lung/pathology[MESH]|Middle Aged[MESH]|Pathology, Surgical/*methods[MESH]|Retrospective Studies[MESH]|Vasculitis/*immunology/pathology[MESH] |