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lüll The genetic control of eye development and its implications for the evolution of the various eye-types Gehring WJInt J Dev Biol 2002[Jan]; 46 (1): 65-73Mutations in the Pax 6 homologs of mammals and insects prevent eye development and targeted expression of both mammal and insect Pax 6 homologs is capable of inducing functional ectopic eyes. Supported by RNA interference experiments in planarians and nemerteans, these findings indicate that Pax 6 is a universal master control gene for eye morphogenesis. Since all metazoan eyes use rhodopsin as a photoreceptor molecule and the same master control gene for eye development, we postulate a monophyletic origin of the various eye types. The finding of well developed eyes in jellyfish which essentially lack a brain, leads us to propose that the eye as a sensory organ evolved before the brain which is an information processing organ. The finding of highly developed eyes with a lens, vitreous body, stacked membranes like a retina and shielding pigment in unicellular dinoflagellates, raises the possibility that the prototypic eyes might have been acquired from symbionts.|*Mutation[MESH]|*Ocular Physiological Phenomena[MESH]|Animals[MESH]|Eye Proteins[MESH]|Eye/*embryology[MESH]|Gene Expression Regulation, Developmental[MESH]|Homeodomain Proteins/metabolism[MESH]|Models, Biological[MESH]|Oligonucleotide Array Sequence Analysis[MESH]|PAX6 Transcription Factor[MESH]|Paired Box Transcription Factors[MESH]|RNA/metabolism[MESH]|Repressor Proteins[MESH] |