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Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway Schell T; Kulozik AE; Hentze MWGenome Biol 2002[]; 3 (3): REVIEWS1006When pre-mRNAs are spliced, a multi-component complex is deposited onto them, close to the sites of intron removal. New findings suggest that these exon-exon junction complexes and the complexes that bind mRNA caps are key effectors of the fate of spliced mRNAs and may regulate whether mRNAs containing premature stop codons are degraded.|Animals[MESH]|Codon, Nonsense/*genetics[MESH]|Exons/genetics[MESH]|Humans[MESH]|Models, Genetic[MESH]|Protein Biosynthesis/*genetics[MESH]|Quality Control[MESH]|RNA Cap-Binding Proteins[MESH]|RNA Splicing/*genetics[MESH]|RNA, Messenger/*genetics/*metabolism[MESH]|RNA-Binding Proteins/genetics/physiology[MESH] |
