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lüll Musashi: a translational regulator of cell fate Okano H; Imai T; Okabe MJ Cell Sci 2002[Apr]; 115 (Pt 7): 1355-9Transcription is thought to have a major role in the regulation of cell fate; the importance of translational regulation in this process has been less certain. Recent findings demonstrate that translational regulation contributes to cell-fate specification. The evolutionarily conserved, neural RNA-binding protein Musashi, for example, controls neural cell fate. The protein functions in maintenance of the stem-cell state, differentiation, and tumorigenesis by repressing translation of particular mRNAs. In mammals it might play an important role in activating Notch signalling by repressing translation of the Notch inhibitor m-Numb.|*Gene Expression Regulation, Developmental[MESH]|*Protein Biosynthesis[MESH]|Animals[MESH]|Caenorhabditis elegans/embryology/genetics[MESH]|Cell Division[MESH]|Drosophila/cytology/embryology/genetics[MESH]|Genes, Regulator[MESH]|Models, Genetic[MESH]|Nervous System/cytology/embryology/metabolism[MESH] |