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lüll Hodgkin s lymphoma: the pathologist s viewpoint Pileri SA; Ascani S; Leoncini L; Sabattini E; Zinzani PL; Piccaluga PP; Pileri A Jr; Giunti M; Falini B; Bolis GB; Stein HJ Clin Pathol 2002[Mar]; 55 (3): 162-76Despite its well known histological and clinical features, Hodgkin's lymphoma (HL) has recently been the object of intense research activity, leading to a better understanding of its phenotype, molecular characteristics, histogenesis, and possible mechanisms of lymphomagenesis. There is complete consensus on the B cell derivation of the tumour in most cases, and on the relevance of Epstein-Barr virus infection and defective cytokinesis in at least a proportion of patients. The REAL/WHO classification recognises a basic distinction between lymphocyte predominance HL (LP-HL) and classic HL (CHL), reflecting the differences in clinical presentation and behaviour, morphology, phenotype, and molecular features. CHL has been classified into four subtypes: lymphocyte rich, nodular sclerosing, with mixed cellularity, and lymphocyte depleted. The borders between CHL and anaplastic large cell lymphoma have become sharper, whereas those between LP-HL and T cell rich B cell lymphoma remain ill defined. Treatments adjusted to the pathobiological characteristics of the tumour in at risk patients have been proposed and are on the way to being applied.|Diagnosis, Differential[MESH]|Genotype[MESH]|Hodgkin Disease/classification/genetics/*pathology[MESH]|Humans[MESH]|Lymphoma, Non-Hodgkin/pathology[MESH]|Phenotype[MESH]|Sclerosis[MESH] |