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NFAT: ubiquitous regulator of cell differentiation and adaptation Horsley V; Pavlath GKJ Cell Biol 2002[Mar]; 156 (5): 771-4The nuclear factor of activated T cells (NFAT) proteins are a family of transcription factors whose activation is controlled by calcineurin, a Ca(2+)-dependent phosphatase. Originally identified in T cells as inducers of cytokine gene expression, NFAT proteins play varied roles in cells outside of the immune system. This review addresses the recent data implicating NFAT in the control of gene expression influencing the development and adaptation of numerous mammalian cell types.|*Nuclear Proteins[MESH]|Adaptation, Physiological/*physiology[MESH]|Animals[MESH]|Calcineurin/genetics/metabolism[MESH]|Cell Differentiation/*physiology[MESH]|Cell Survival/*physiology[MESH]|DNA-Binding Proteins/genetics/*metabolism[MESH]|Gene Expression Regulation, Developmental/*physiology[MESH]|Humans[MESH]|Muscles/metabolism[MESH]|NFATC Transcription Factors[MESH]|Signal Transduction/*physiology[MESH]|Transcription Factors/genetics/*metabolism[MESH] |
