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lüll Role of primary intrahepatic T-cell activation in the liver tolerance effect Bertolino P; McCaughan GW; Bowen DGImmunol Cell Biol 2002[Feb]; 80 (1): 84-92There is accumulating evidence suggesting that hepatic permeability to both naive and activated T lymphocytes may be unique among the solid organs. The possibility that the liver may act as a site of primary activation for CD8+ T lymphocytes is supported by experimental data and may contribute to some of the unique immunological properties of this organ, particularly its ability to induce antigen-specific tolerance. This review discusses the nature of the liver APC inducing primary T-cell activation within the liver: Kupffer cells, liver dendritic cells, liver sinusoidal endothelial cells and hepatocytes are favourably located to allow physical contact with circulating T lymphocytes. Here, we examine the capability of each cell type to act as APC for naive CD4+ or CD8+ T cells and to induce tolerance.|Animals[MESH]|CD4-Positive T-Lymphocytes/*immunology[MESH]|CD8-Positive T-Lymphocytes/*immunology[MESH]|Humans[MESH]|Immune Tolerance/*immunology[MESH]|Liver/cytology/*immunology[MESH]|Lymphocyte Activation/*immunology[MESH] |