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lüll Opening chromatin Lomvardas S; Thanos DMol Cell 2002[Feb]; 9 (2): 209-11How the transcriptional apparatus gains access to and subsequently opens compacted chromatin has remained a mystery. Now in this issue of Molecular Cell, Zaret and coworkers show that chromatin opening in vitro is not mediated by the classical chromatin remodeling machines but instead occurs through specific transcription factor-histone interactions.|Animals[MESH]|Chromatin/genetics/metabolism/*ultrastructure[MESH]|DNA-Binding Proteins/physiology[MESH]|Endoderm/metabolism[MESH]|Enhancer Elements, Genetic/physiology[MESH]|Fetal Proteins/biosynthesis/genetics[MESH]|GATA4 Transcription Factor[MESH]|Gene Expression Regulation, Developmental/*physiology[MESH]|Gene Silencing[MESH]|Hepatocyte Nuclear Factor 3-alpha[MESH]|Histones/*physiology[MESH]|Liver/embryology/metabolism[MESH]|Macromolecular Substances[MESH]|Mice[MESH]|Models, Genetic[MESH]|Nuclear Proteins/physiology[MESH]|Nucleosomes/physiology[MESH]|Promoter Regions, Genetic/physiology[MESH]|Serum Albumin/biosynthesis/genetics[MESH]|Transcription Factors/*physiology[MESH]|Transcription, Genetic/*physiology[MESH] |