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lüll Almotriptan: a review of pharmacology, clinical efficacy, and tolerability Von SAm J Manag Care 2002[Feb]; 8 (3 Suppl): S74-9OBJECTIVE: This article summarizes preclinical and clinical data for almotriptan. METHODS: Almotriptan has been evaluated in more than 3,500 acute migraine patients in phase 2 and 3 double-blind, randomized trials and in 1,500 patients in long-term open-label trials. RESULTS: Controlled clinical trials show that almotriptan 12.5 mg is significantly more effective than placebo. These results are observed across different endpoints examined, including pain relief at 2 hours, pain-free outcome at 2 hours, recurrence rate, use of escape medication, and sustained pain-free outcome. The onset of pain relief is observed as early as 30 minutes after administration. Results from a multiple-attack study show that almotriptan maintains a consistency of response across 3 attacks, and results from long-term studies confirm that patients continue to respond to almotriptan for up to 1 year. Results from 2 comparative studies show that almotriptan 12.5 mg has comparable efficacy to sumatriptan 50 or 100 mg, but almotriptan has a superior tolerability profile. Early use of almotriptan results in a higher proportion of patients achieving pain relief or complete freedom from pain. CONCLUSIONS: Because almotriptan has a tolerability profile comparable to that of placebo, it may be more acceptable for early administration. The incidence of treatment-related adverse events with almotriptan is comparable to that of placebo and significantly lower than recorded with sumatriptan. In addition, almotriptan has a low incidence of chest symptoms, an adverse event associated with triptan use. Because of its comparable efficacy and superior tolerability profile, almotriptan offers a potential improvement over existing triptans for the treatment of acute migraine.|Clinical Trials, Phase II as Topic[MESH]|Clinical Trials, Phase III as Topic[MESH]|Double-Blind Method[MESH]|Humans[MESH]|Indoles/adverse effects/*pharmacology/therapeutic use[MESH]|Migraine Disorders/*drug therapy[MESH]|Randomized Controlled Trials as Topic[MESH]|Serotonin Receptor Agonists/adverse effects/*pharmacology/therapeutic use[MESH]|Tryptamines[MESH]|United States[MESH] |