Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
ONYX-015: mechanisms of action and clinical potential of a replication-selective adenovirus Ries S; Korn WMBr J Cancer 2002[Jan]; 86 (1): 5-11Accumulated knowledge in the molecular processes of tumour development combined with the availability of genetically modified viruses resemble the basis for new promising cancer therapeutics. The main advantages of employing replication-competent viruses are achievement of tumour selective killing and amplification of their oncolytic potential within the tumour mass. In this review, we describe the development of ONYX-015, one of the first and most advanced replication-competent viruses for cancer therapy. We discuss the molecular biology of this therapeutic approach and the interesting results obtained with this virus in clinical trials.|*Genetic Therapy[MESH]|Adenoviridae/*genetics[MESH]|Animals[MESH]|Cell Cycle[MESH]|Clinical Trials as Topic[MESH]|Genetic Vectors/administration & dosage[MESH]|Humans[MESH]|Neoplasms/*therapy[MESH]|Tumor Suppressor Protein p53/physiology[MESH]|Virus Replication[MESH] |
