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lüll Pain pathways and parabrachial circuits in the rat Gauriau C; Bernard JFExp Physiol 2002[Mar]; 87 (2): 251-8This review presents a schematic attempt to classify the major pain pathways, based on the results of recent studies in our laboratory, with a special emphasis on the parabrachial system. Our view is based on results from experiments in the rat, using very small iontophoretic injections of anterograde tracers. As illustrated in this report, we have found a very dramatic difference between ascending projections originating from deep laminae compared with those arising from lamina I of the dorsal horn. We propose three main pain systems and discuss their functional-anatomical relationships. The first system is centred on the projection from deep laminae to three caudal reticular areas - the lateral reticular nucleus (LRN), the subnucleus reticularis dorsalis (SRD) and the gigantocellular lateral paragigantocellular reticular nuclei (NGc) - and the parabrachial internal lateral subnucleus (PBil). The second system is centred on the projection from lamina I to the ventral posterolateral nucleus (VPL), the ventral posteromedial (VPM), the posterior nuclear group (Po) and triangular posterior nucleus (PoT) of the thalamus. The third system is centred on the projection from lamina I to the lateral parabrachial area. We also present the four main projections from the latter area to the extended amygdala, the hypothalamus, the periaqueductal grey matter (PAG), and the ventrolateral medulla (VLM), and their involvement in emotional and autonomic (homeostatic) aspects of pain.|Amygdala/*cytology/physiology[MESH]|Animals[MESH]|Medulla Oblongata/cytology/physiology[MESH]|Neurons, Afferent/*physiology[MESH]|Pain/*physiopathology[MESH]|Periaqueductal Gray/*cytology/physiology[MESH]|Pons/cytology/physiology[MESH]|Rats[MESH]|Reticular Formation/*cytology/physiology[MESH]|Thalamus/*cytology/physiology[MESH] |