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lüll Cutting-edge technology I Global gene expression profiling using DNA microarrays Arcellana-Panlilio M; Robbins SMAm J Physiol Gastrointest Liver Physiol 2002[Mar]; 282 (3): G397-402Having the complete human genomic sequence poses a new challenge: to use genomic structural information to display and analyze biological processes on a genome-wide scale to assign gene function. DNA microarrays are a miniaturized, ordered arrangement of nucleic acid fragments from individual genes located at defined positions on a solid support, enabling the analysis of thousands of genes in parallel by specific hybridization. This review describes technical aspects, discusses relevant applications, and suggests factors affecting the use of this technology and how it fits in the grand scheme of meeting the needs of the postgenomic era.|*Gene Expression Profiling[MESH]|*Oligonucleotide Array Sequence Analysis[MESH]|Aging/genetics[MESH]|Animals[MESH]|Chemical and Drug Induced Liver Injury[MESH]|Humans[MESH]|Immunity/genetics[MESH]|Liver Diseases/genetics[MESH]|Neoplasms/genetics[MESH] |