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Thrombin regulation of cell function through protease-activated receptors: implications for therapeutic intervention Derian CK; Damiano BP; D'Andrea MR; Andrade-Gordon PBiochemistry (Mosc) 2002[Jan]; 67 (1): 56-64The serine protease thrombin is well recognized as being pivotal to the maintenance of hemostasis under both normal and pathological conditions. Its cellular actions are mediated through a unique family of protease-activated receptors (PARs). These receptors represent a novel family of G protein-coupled receptors that undergo proteolytic cleavage of their amino terminus and subsequent autoactivation by a tethered peptide ligand. This paper reviews the consequences of PAR activation in thrombosis, vascular injury, inflammation, tissue injury, and within the tumor microenvironment.|Animals[MESH]|Endopeptidases/*metabolism[MESH]|Humans[MESH]|Models, Biological[MESH]|Neoplasms/metabolism[MESH]|Receptor, PAR-1[MESH]|Receptors, Thrombin/*metabolism[MESH]|Thrombin/*metabolism[MESH]|Thrombosis[MESH] |