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lüll The Id proteins and angiogenesis Benezra R; Rafii S; Lyden DOncogene 2001[Dec]; 20 (58): 8334-41Since the identification of the Id proteins over a decade ago, a great many cell cycle and cell fate decisions have been shown to be under the control of these proteins as described in other sections of this review issue. Perhaps the most unsuspected activity of this class of proteins has been their essential role in angiogenesis, both in the forebrain during development and during the growth and metastasis of tumors in adults. This section of the review issue will focus on the key observations which have led to these conclusions, speculations about potential mechanisms and the outlook for potential therapeutic interventions.|*Multigene Family[MESH]|*Repressor Proteins[MESH]|Animals[MESH]|Blood Vessels/injuries[MESH]|Bone Marrow Cells/cytology[MESH]|Cell Differentiation[MESH]|DNA-Binding Proteins/deficiency/genetics/*physiology[MESH]|Dogs[MESH]|Endothelial Growth Factors/physiology[MESH]|Endothelium, Vascular/cytology[MESH]|Helix-Loop-Helix Motifs[MESH]|Hematopoietic Stem Cells/cytology[MESH]|Humans[MESH]|Inhibitor of Differentiation Protein 1[MESH]|Inhibitor of Differentiation Protein 2[MESH]|Inhibitor of Differentiation Proteins[MESH]|Lymphokines/physiology[MESH]|Mice[MESH]|Mice, Knockout[MESH]|Neoplasm Proteins/genetics/physiology[MESH]|Neoplasms/blood supply/genetics[MESH]|Neovascularization, Pathologic/genetics/physiopathology[MESH]|Neovascularization, Physiologic/genetics/*physiology[MESH]|Proto-Oncogene Proteins/physiology[MESH]|Receptor Protein-Tyrosine Kinases/physiology[MESH]|Receptors, Growth Factor/physiology[MESH]|Receptors, Vascular Endothelial Growth Factor[MESH]|Stem Cells/cytology[MESH]|Transcription Factors/deficiency/genetics/*physiology[MESH]|Vascular Endothelial Growth Factor A[MESH]|Vascular Endothelial Growth Factor Receptor-1[MESH]|Vascular Endothelial Growth Factors[MESH] |