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Radiation therapy and combination of cladribine, cyclophosphamide, and prednisone as treatment of Bing-Neel syndrome: Case report and review of the literature Delgado J; Canales MA; Garcia B; Alvarez-Ferreira J; Garcia-Grande A; Hernandez-Navarro FAm J Hematol 2002[Feb]; 69 (2): 127-31Waldenstrom's macroglobulinemia is a low-grade lymphoma that produces monoclonal IgM. Central nervous system symptoms are frequent in Waldenstrom's macroglobulinemia, mostly associated with blood hyperviscosity. Nevertheless, central nervous system infiltration by malignant cells (Bing-Neel syndrome) has rarely been reported. We describe the case of a 72-year-old man with Waldenstrom's macroglobulinemia and central nervous system infiltration by malignant cells with tumor formation. All similar cases reported in the literature are reviewed and the different therapeutic approaches discussed.|Aged[MESH]|Antineoplastic Combined Chemotherapy Protocols/*therapeutic use[MESH]|Biopsy[MESH]|Bone Marrow/pathology[MESH]|Brain/*pathology[MESH]|Cladribine/therapeutic use[MESH]|Combined Modality Therapy[MESH]|Cyclophosphamide/therapeutic use[MESH]|Dizziness[MESH]|Glucocorticoids/therapeutic use[MESH]|Humans[MESH]|Immunoglobulin M/blood[MESH]|Magnetic Resonance Imaging[MESH]|Male[MESH]|Muscle Weakness[MESH]|Prednisone/therapeutic use[MESH]|Stereotaxic Techniques[MESH]|Waldenstrom Macroglobulinemia/diagnosis/drug therapy/*pathology/radiotherapy/*therapy[MESH] |
