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Cancer as a complex genetic trait: tumor susceptibility in humans and mouse models Balmain ACell 2002[Jan]; 108 (2): 145-52Cancer directly affects at least one-third of the human population, but the inherited genetic determinants of cancer risk remain largely unknown. Mouse models of human cancer are helping us to understand this disease as a complex genetic trait and thus to identify the multiple genetic variant alleles involved in pathways that affect individual cancer susceptibility.|*Disease Models, Animal[MESH]|*Genetic Predisposition to Disease[MESH]|Alleles[MESH]|Animals[MESH]|Humans[MESH]|Mice[MESH]|Models, Biological[MESH]|Neoplasms/*genetics[MESH]|Quantitative Trait, Heritable[MESH]|Risk Factors[MESH] |