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lüll The biochemical pathology of liver cell necrosis Farber JL; El-Mofty SKAm J Pathol 1975[Oct]; 81 (1): 237-50Cell death and necrosis are important reactions of liver cells to injury that play a role in a wide variety of human liver diseases. A review is given of the important facets known about the biochemical basis of toxic liver cell death. Liver cells can withstand a great many specific biochemical and morphologic changes without loss of viability. Disturbances in RNA and protein synthesis, mitochondrial function, or release of lysosomal enzymes do not play a primary causative role in cell death. Many previous studies have tended to implicate the plasma membrane and its presumed role in maintaining the proper Ca2+ balance as the primary site of the development of irreversible hepatocyte damage. These studies have generally faced a major difficulty in determining if the observed changes are the cause or an effect of cell death. Galactosamine-induced liver cell injury seems to offer a potentially analyzable model for the experimental analysis of liver cell necrosis. Our studies on the role of plasma membrane injury and associated increases in total cellular calcium are reviewed, and a tentative working hypothesis for the pathogenesis of galactosamine-induced liver cell necrosis is presented.|Animals[MESH]|Calcium/metabolism[MESH]|Cell Membrane/drug effects[MESH]|Cell Survival[MESH]|Chemical and Drug Induced Liver Injury/*pathology[MESH]|Galactosamine[MESH]|Humans[MESH]|Liver/*drug effects/metabolism/pathology[MESH]|Lysosomes/drug effects/metabolism[MESH]|Mitochondria, Liver/drug effects/metabolism[MESH]|Necrosis[MESH]|Protein Biosynthesis[MESH]|RNA/biosynthesis[MESH]|Rats[MESH]|Uridine/pharmacology[MESH] |