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lüll Prevalence of circulating antibodies to p10, a non-structural protein of the Borna disease virus in cats with ataxia Ouchi A; Kishi M; Kobayashi T; Lai PK; Malik TH; Ikuta K; Mochizuki MJ Vet Med Sci 2001[Dec]; 63 (12): 1279-85Japanese domestic cats were surveyed for circulating antibodies to the plO and p24 proteins of the Borna disease virus (BDV) by Western blotting. Twenty-four of 52 cats (46.2%) with ataxia and other neurologic symptoms of unknown cause were positive for antibodies to BDV p10 and/or p24. In contrast, cats without neurological symptoms gave a significantly lower prevalence of anti-BDV antibodies to p10 and/or p24 (36 of 152 cats, 23.7%). Thirty specific pathogen-free (SPF) cats tested as controls were uniformly negative to BDV pl0 and p24 antigens. These results suggest that BDV may play a role in ataxia in cats. Additionally, our results suggest that it is necessary to use both p10 and p24 as antigens to detect circulating antibodies to BDV in cats.|Animals[MESH]|Antibodies, Viral/*blood[MESH]|Ataxia/immunology/*veterinary/virology[MESH]|Borna Disease/blood/epidemiology/*immunology[MESH]|Borna disease virus/*immunology[MESH]|Cat Diseases/epidemiology/*immunology/virology[MESH]|Cats[MESH]|Female[MESH]|Japan/epidemiology[MESH]|Male[MESH]|Seroepidemiologic Studies[MESH]|Specific Pathogen-Free Organisms[MESH]|Viral Proteins/*immunology[MESH] |