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Traffic through the Golgi apparatus Pelham HRJ Cell Biol 2001[Dec]; 155 (7): 1099-101The role of vesicles in cargo transport through the Golgi apparatus has been controversial. Large forms of cargo such as protein aggregates are thought to progress through the Golgi stack by a process of cisternal maturation, balanced by a return flow of Golgi resident proteins in COPI-coated vesicles. However, whether this is the primary role of vesicles, or whether they also serve to transport small cargo molecules in a forward direction has been debated. Two papers (Martinez-Menarguez et al., 2001; Mironov et al., 2001, this issue) use sophisticated light and electron microscopy to provide evidence that the vesicular stomatitis virus membrane glycoprotein (VSV G)* is largely excluded from vesicles in vivo, and does not move between cisternae, whereas resident Golgi enzymes freely enter vesicles as predicted by the cisternal maturation model. Both papers conclude that vesicles are likely to play only a minor role in the anterograde transport of cargo through the Golgi apparatus in mammalian tissue culture cells.|*Membrane Glycoproteins[MESH]|*Protein Transport[MESH]|COP-Coated Vesicles/physiology[MESH]|Golgi Apparatus/*physiology/ultrastructure[MESH]|Humans[MESH]|Models, Biological[MESH]|Saccharomyces cerevisiae/physiology/ultrastructure[MESH]|Vesicular stomatitis Indiana virus/physiology[MESH]|Viral Envelope Proteins/metabolism[MESH] |
