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lüll Chorioallantoic membrane capillary bed: a useful target for studying angiogenesis and anti-angiogenesis in vivo Ribatti D; Nico B; Vacca A; Roncali L; Burri PH; Djonov VAnat Rec 2001[Dec]; 264 (4): 317-24The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane that is commonly used in vivo to study both angiogenesis and anti-angiogenesis. This review 1) summarizes the current knowledge about the structure of the CAM's capillary bed; 2) discusses the controversy about the existence of a single blood sinus or a capillary plexus underlying the chorionic epithelium; 3) describes a new model of the CAM vascular growth, namely the intussusceptive mode; 4) reports findings regarding the role played by endogenous fibroblast growth factor-2 in CAM vascularization; and 5) addresses the use and limitations of the CAM as a model for studying angiogenesis and anti-angiogenesis.|Allantois/*blood supply/embryology/physiology[MESH]|Angiogenesis Inhibitors/*physiology/therapeutic use[MESH]|Animals[MESH]|Capillaries/anatomy & histology/physiology[MESH]|Chick Embryo[MESH]|Chorion/*blood supply/embryology/physiology[MESH]|Fibroblast Growth Factor 2/physiology[MESH]|Models, Biological[MESH]|Neoplasms/blood supply/drug therapy[MESH]|Neovascularization, Pathologic/drug therapy[MESH]|Neovascularization, Physiologic/drug effects/*physiology[MESH] |