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New approaches to antiarrhythmic therapy: emerging therapeutic applications of the cell biology of cardiac arrhythmias(1) äCardiovasc Res 2001[Dec]; 52 (3): 345-60Cardiac arrhythmias complicate many diseases affecting the heart and the circulation, and incorporate a multiplicity of underlying mechanisms. The evolution of scientific knowledge has made the complex changes produced by cardiovascular disease sufficiently understood at the organ, cellular, and molecular levels such that there is a diversity of therapeutic targets for pharmacological therapy and/or prevention. Moreover, the approach of rational drug design in mechanism-specific and disease-specific fashion facilitates targeting of therapy via the methods of molecular, structural and translational biology. Additional approaches, employing similar drug design strategies but based on gene therapy and transcriptional and translational modification are on the horizon. Hence, there is reason to be optimistic regarding the design, testing and clinical availability of novel antiarrhythmic therapies. CONDENSED ABSTRACT: The evolution of scientific knowledge has made the effects of cardiovascular disease sufficiently understood at the organ, cellular, and molecular levels such that there is a diversity of therapeutic targets for pharmacological therapy and/or prevention. Moreover, the approach of rational drug design facilitates targeting of therapy via the methods of molecular, structural and translational biology. Additional approaches, employing similar drug design strategies but based on gene therapy and transcriptional and translational modification are on the horizon. Hence, there is reason to be optimistic regarding the design, testing and clinical availability of novel antiarrhythmic therapies.|*Computer Simulation[MESH]|*Models, Cardiovascular[MESH]|Angiotensin II/metabolism[MESH]|Anti-Arrhythmia Agents[MESH]|Arrhythmias, Cardiac/metabolism/physiopathology/*therapy[MESH]|Drug Design[MESH]|Electrophysiology[MESH]|GTP-Binding Proteins/genetics[MESH]|Gene Expression Regulation[MESH]|Gene Transfer Techniques[MESH]|Genetic Therapy[MESH]|Heart Conduction System/physiopathology[MESH]|Humans[MESH]|Ion Transport/drug effects[MESH]|Myocardium/metabolism[MESH]|Potassium Channels/genetics[MESH]|Stress, Mechanical[MESH]|Ventricular Remodeling[MESH] |
