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Paraneoplastic optic neuropathy and cerebellar ataxia with small cell carcinoma of the lung Thambisetty MR; Scherzer CR; Yu Z; Lennon VA; Newman NJJ Neuroophthalmol 2001[Sep]; 21 (3): 164-7Bilateral optic neuropathy and subacute cerebellar ataxia were manifestations of a paraneoplastic neurologic disorder in a woman found to have small cell carcinoma of the lung. Serologic tests revealed a neuronal autoantibody specific for CRMP-5, a 62-kd member of the collapsin response-mediating protein family. Unexplained optic neuropathy in the setting of subacute cerebellar ataxia should cause suspicion of a paraneoplastic disorder and prompt testing for this autoantibody, especially in patients at risk for lung carcinoma.|Aged[MESH]|Antibodies, Neoplasm/blood[MESH]|Antigens, Neoplasm/immunology[MESH]|Autoantibodies/blood[MESH]|Biomarkers, Tumor/blood[MESH]|Carcinoma, Small Cell/complications/*pathology[MESH]|Cerebellar Ataxia/*diagnosis/etiology/immunology[MESH]|Fatal Outcome[MESH]|Female[MESH]|Humans[MESH]|Lung Neoplasms/complications/*pathology[MESH]|Nerve Tissue Proteins/immunology[MESH]|Optic Nerve Diseases/*diagnosis/etiology/immunology[MESH]|Paraneoplastic Syndromes/*diagnosis/etiology/immunology[MESH] |
