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English Wikipedia
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Huntington s disease Davies S; Ramsden DBMol Pathol 2001[Dec]; 54 (6): 409-13The most recent findings in the elucidation of the molecular pathology of Huntington's disease are reviewed. Particular interest has been paid to the role of huntingtin and its associated proteins in excitotoxicity mediated via NMDA and kainate receptors.|*DNA-Binding Proteins[MESH]|*Huntington Disease/genetics/metabolism/pathology[MESH]|Apoptosis[MESH]|Brain-Derived Neurotrophic Factor/metabolism[MESH]|Carrier Proteins/metabolism[MESH]|Cell Death[MESH]|Cell Nucleus/metabolism[MESH]|Cytoplasm/metabolism[MESH]|Humans[MESH]|Huntingtin Protein[MESH]|Models, Neurological[MESH]|Nerve Tissue Proteins/genetics/metabolism[MESH]|Neurons/metabolism/pathology[MESH]|Neurotoxins/metabolism[MESH]|Nuclear Proteins/genetics/metabolism[MESH]|Oxidative Stress[MESH]|Receptors, N-Methyl-D-Aspartate/metabolism[MESH]|Trinucleotide Repeat Expansion[MESH] |
