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lüll A short primer on RNAi: RNA-directed RNA polymerase acts as a key catalyst Nishikura KCell 2001[Nov]; 107 (4): 415-8One of the many intriguing features of gene silencing by RNA interference is the apparent catalytic nature of the phenomenon. New biochemical and genetic evidence now shows that an RNA-directed RNA polymerase chain reaction, primed by siRNA, amplifies the interference caused by a small amount of "trigger" dsRNA.|Animals[MESH]|Cell-Free System[MESH]|Drosophila melanogaster/embryology/genetics[MESH]|Endoribonucleases/physiology[MESH]|Gene Silencing/*physiology[MESH]|Gene Targeting[MESH]|Insect Proteins/physiology[MESH]|Models, Genetic[MESH]|Plant Proteins/physiology[MESH]|Polymerase Chain Reaction/methods[MESH]|RNA Processing, Post-Transcriptional[MESH]|RNA, Double-Stranded/pharmacology/physiology[MESH]|RNA, Messenger/*antagonists & inhibitors/genetics/metabolism[MESH]|RNA, Small Interfering[MESH]|RNA, Untranslated/genetics/*physiology[MESH]|RNA-Dependent RNA Polymerase/*physiology[MESH]|Ribonuclease III[MESH]|Sequence Homology, Nucleic Acid[MESH] |