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lüll Recent advances in our understanding of human host responses to tuberculosis Schluger NWRespir Res 2001[]; 2 (3): 157-63Tuberculosis remains one of the world's greatest public health challenges: 2 billion persons have latent infection, 8 million people develop active tuberculosis annually, and 2-3 million die. Recently, significant advances in our understanding of the human immune response against tuberculosis have occurred. The present review focuses on recent work in macrophage and T-cell biology that sheds light on the human immune response to tuberculosis. The role of key cytokines such as interferon-gamma is discussed, as is the role of CD4+ and CD8+ T cells in immune regulation in tuberculosis, particularly with regard to implications for vaccine development and evaluation.|Animals[MESH]|Antibody Formation/physiology[MESH]|Genetic Predisposition to Disease[MESH]|Humans[MESH]|Macrophages/physiology[MESH]|Phagocytosis/physiology[MESH]|T-Lymphocytes/physiology[MESH]|Tuberculosis/genetics/*immunology[MESH] |