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Down-regulated melanoma differentiation associated gene (mda-7) expression in human melanomas Ekmekcioglu S; Ellerhorst J; Mhashilkar AM; Sahin AA; Read CM; Prieto VG; Chada S; Grimm EAInt J Cancer 2001[Oct]; 94 (1): 54-9The melanoma differentiation associated gene-7 (mda-7) has a potential inhibitory role in melanoma progression, although the mechanisms underlying this effect are still unknown. mda-7 mRNA has been found to be present at higher levels in cultured normal melanocytes compared with metastatic melanoma cell lines. Furthermore, levels of mda-7 message have shown an inverse correlation with melanoma progression in human tumor samples, suggesting that mda-7 may be a novel tumor suppressor gene. We have designed this study to investigate MDA-7 protein expression in different stages of melanoma progression and to examine its antiproliferative effects in vitro. Our data demonstrate that MDA-7 protein can be found in normal melanocytes and early stage melanomas. It is also observed in smooth muscle cells in the skin. However, in keeping with a possible role as a tumor suppressor, MDA-7 expression is decreased in more advanced melanomas, with nearly undetectable levels in metastatic disease. We also investigated antitumor effects of overexpressed MDA-7 on human melanoma cells in vitro. Our results demonstrate that Ad-mda-7 induces apoptosis and G2/M cell cycle arrest in melanoma cells, but not in normal human melanocytes.|*Gene Expression Regulation, Neoplastic[MESH]|*Interleukins[MESH]|Apoptosis[MESH]|Cell Differentiation[MESH]|Cell Division[MESH]|Cytoplasm/chemistry[MESH]|Down-Regulation[MESH]|G2 Phase[MESH]|Genes, Tumor Suppressor[MESH]|Growth Substances/analysis/*genetics/physiology[MESH]|Humans[MESH]|Melanocytes/*chemistry[MESH]|Melanoma/*metabolism/pathology/secondary[MESH]|Mitosis[MESH]|Tumor Cells, Cultured[MESH] |
