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lüll The transmembrane adapter LAT plays a central role in immune receptor signalling Wonerow P; Watson SPOncogene 2001[Oct]; 20 (44): 6273-83The transmembrane adapter LAT (linker for activation of T cells) plays a central role in signalling by ITAM bearing receptors expressed on T cells, natural killer cells, mast cells and platelets. Receptor engagement leads to the phosphorylation of tyrosine residues present in the intracellular domain of LAT and formation of a multiprotein complex with other adapter molecules and enzymes including Grb2, Gads/SLP-76 and PLCgamma isoforms. These signalling events predominantly take place in glycolipid-enriched membrane domains. The constitutive presence of LAT in GEMs enables its function as the main scaffolding protein for the organization of GEM-localized signalling. The study of LAT-deficient mice and LAT-deficient cell lines further emphasizes the importance of LAT for these signalling cascades but also defines the existence of LAT-independent events downstream of the Syk-family kinase-ITAM complex.|*Adaptor Proteins, Signal Transducing[MESH]|*Membrane Proteins[MESH]|*Signal Transduction[MESH]|Animals[MESH]|B-Lymphocytes/metabolism[MESH]|Blood Platelets/metabolism[MESH]|Carrier Proteins/*metabolism/*physiology[MESH]|Cell Membrane/metabolism[MESH]|Humans[MESH]|Killer Cells, Natural/metabolism[MESH]|Models, Biological[MESH]|Phosphoproteins/*metabolism/*physiology[MESH]|Phosphorylation[MESH]|Protein Binding[MESH]|Protein Structure, Tertiary[MESH]|T-Lymphocytes/metabolism[MESH]|Type C Phospholipases/metabolism[MESH]|Tyrosine/metabolism[MESH] |