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Antiaging compounds: (-)deprenyl (selegeline) and (-)1-(benzofuran-2-yl)-2-propylaminopentane, (-)BPAP , a selective highly potent enhancer of the impulse propagation mediated release of catecholamine and serotonin in the brain Knoll JCNS Drug Rev 2001[Fal]; 7 (3): 317-45Hundreds of millions of people now die over the age of 80 years primarily due to twentieth century progress in hygiene, chemotherapy, and immunology. With a longer average lifespan, the need to improve quality of life during the latter decades is more compelling. "Aging--The Epidemic of the New Millenium," a recent international conference (Monte Carlo, June 17-18, 2000), showed with peculiar clarity that a safe and efficient drug strategy to slow the age-related decay of brain performance is still missing. This review summarizes the physiologic and pharmacologic arguments in favor of a peculiar lifelong prophylactic medication with reasonable chances to keep in check brain aging and decrease the precipitation of age-related neurological diseases.|Aging/*drug effects[MESH]|Alzheimer Disease/drug therapy[MESH]|Animals[MESH]|Benzofurans/*pharmacology[MESH]|Brain/*drug effects/metabolism[MESH]|Catecholamines/*metabolism[MESH]|Depression/drug therapy[MESH]|Humans[MESH]|Neuroprotective Agents/*pharmacology[MESH]|Parkinson Disease/drug therapy[MESH]|Propylamines/pharmacology[MESH]|Selegiline/*pharmacology[MESH]|Serotonin/*metabolism[MESH] |
