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lüll Neuropathic central pain: epidemiology, etiology, and treatment options Schwartzman RJ; Grothusen J; Kiefer TR; Rohr PArch Neurol 2001[Oct]; 58 (10): 1547-50BACKGROUND: Nociceptive pain is a major problem in clinical neurology. Peripheral nerve injury may change the physiology of the dorsal horn so that pain becomes progressively centralized. OBJECTIVE: To review mechanisms underlying the plasticity of dorsal root ganglia and dorsal horn neurons that lead to central pain from a peripheral nerve injury. RESULTS: Evidence is reviewed that points to molecular changes in nociceptive terminals, ectopic firing of afferent pain fibers at the level of the dorsal root ganglia, and physiologic changes of the N-methyl-D-aspartate receptor that cause chronic nociceptive pain. CONCLUSIONS: Central sensitization is the physiologic manifestation of many severe peripherally induced pain states. It is maintained by nociceptive input and a physiologic change in the N-methyl-D-aspartate receptor. It consists of: (1) hypersensitivity at the site of injury; (2) mechanoallodynia; (3) thermal hyperalgesia; (4) hyperpathia; (5) extraterritoriality in the case of complex regional pain syndrome/reflex sympathetic dystrophy; and (6) associated neurogenic inflammation, autonomic dysregulation, and motor phenomena.|*Pain Management[MESH]|Central Nervous System Diseases/*epidemiology/*etiology/*therapy[MESH]|Humans[MESH]|Hyperalgesia/physiopathology[MESH]|Hypersensitivity/physiopathology[MESH]|Motor Activity/physiology[MESH]|Neuralgia/epidemiology[MESH]|Pain/*epidemiology/*etiology/physiopathology[MESH]|Receptors, N-Methyl-D-Aspartate/physiology[MESH]|Syndrome[MESH] |