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lüll Typing of Clostridium difficile Brazier JSClin Microbiol Infect 2001[Aug]; 7 (8): 428-31Clostridium difficile is primarily recognised as a nosocomially acquired pathogen manifesting in gastrointestinal disease subsequent to the patient receiving broad-spectrum antibiotics. Infection can be sporadic, but outbreaks commonly occur within a ward or hospital as a result of cross-infection. Since the 1980s, the epidemiology of C. difficile disease has been studied by the application of many different typing or fingerprinting methods; these, and the lessons learned, are reviewed herein.|Clostridioides difficile/chemistry/*classification/genetics[MESH]|Cross Infection/epidemiology/microbiology[MESH]|DNA, Bacterial/chemistry/genetics[MESH]|Electrophoresis, Gel, Pulsed-Field/methods[MESH]|Enterocolitis, Pseudomembranous/epidemiology/microbiology[MESH]|Genetic Variation[MESH]|Humans[MESH]|Polymerase Chain Reaction/methods[MESH]|Polymorphism, Restriction Fragment Length[MESH]|Random Amplified Polymorphic DNA Technique/methods[MESH]|Ribotyping/methods[MESH]|United Kingdom/epidemiology[MESH] |