Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Role of ABCG1 and other ABCG family members in lipid metabolism Schmitz G; Langmann T; Heimerl SJ Lipid Res 2001[Oct]; 42 (10): 1513-20The molecular cloning and identification of mutations in ATP-binding cassette transporters in hereditary diseases have greatly expanded our knowledge of the normal physiology of intracellular lipid transport processes. In addition to the well-known ATP-binding cassette transporter A1 (ABCA1) molecule, ABC transporters belonging to the ABCG (White) subfamily (ABCG1, ABCG5, and ABCG8) have been shown to be critically involved in the regulation of lipid-trafficking mechanisms in macrophages, hepatocytes, and intestinal mucosa cells. ABCG1, the product of a sterol-induced gene, participates in cholesterol and phospholipid efflux. The ABCG5 and ABCG8 transporters, defective in beta-sitosterolemia, are also now considered interesting targets in the control and influence of total body sterol homeostasis. In this review, advances referring to the regulation and function of ABCG half-size transporters are summarized and discussed. In addition, new implications for the transcriptional control, as well as the intracellular routing and localization, of these proteins are presented.|*Lipid Metabolism[MESH]|ATP Binding Cassette Transporter, Subfamily G, Member 1[MESH]|ATP Binding Cassette Transporter, Subfamily G, Member 5[MESH]|ATP Binding Cassette Transporter, Subfamily G, Member 8[MESH]|ATP-Binding Cassette Transporters/*metabolism[MESH]|Adenosine Triphosphate/metabolism[MESH]|Animals[MESH]|Drosophila Proteins/metabolism[MESH]|Gene Expression Profiling[MESH]|Humans[MESH]|Lipoproteins/metabolism[MESH]|Sterols/metabolism[MESH] |
