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Common themes in mechanisms of gene silencing Moazed DMol Cell 2001[Sep]; 8 (3): 489-98The assembly of DNA into regions of inaccessible chromatin, called silent chromatin, is involved in the regulation of gene expression and maintenance of chromosome stability in eukaryotes. Recent studies on Sir2-containing silencing complexes in budding yeast and HP1- and Swi6-containing silencing complexes in metazoans and fission yeast suggest a common mechanism for the assembly of these domains, which involves the physical coupling of histone modifying enzymes to histone binding proteins.|*Gene Silencing[MESH]|*Saccharomyces cerevisiae Proteins[MESH]|*Silent Information Regulator Proteins, Saccharomyces cerevisiae[MESH]|Animals[MESH]|Chromatin/metabolism[MESH]|Chromosomal Proteins, Non-Histone/metabolism[MESH]|Fungal Proteins[MESH]|Gene Expression Regulation/physiology[MESH]|Histone Deacetylases/metabolism[MESH]|Histones/metabolism[MESH]|Humans[MESH]|RNA, Ribosomal/genetics/metabolism[MESH]|Sirtuin 1[MESH]|Sirtuin 2[MESH]|Sirtuins[MESH]|Trans-Activators/metabolism[MESH]|Transcription Factors[MESH]|Yeasts/genetics[MESH] |
