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lüll Stiff-person syndrome associated with cerebellar ataxia and high glutamic acid decarboxylase antibody titer Kono S; Miyajima H; Sugimoto M; Suzuki Y; Takahashi Y; Hishida AIntern Med 2001[Sep]; 40 (9): 968-71Glutamic acid decarboxylase (GAD) is the main target of humoral autoimmunity in patients with insulin-dependent diabetes mellitus (IDDM) and stiff-person syndrome. We reviewed the case of a 46-year-old woman who had cerebellar ataxia before getting stiff-person syndrome and IDDM with high anti-GAD autoantibody titers. This was a rare case in which there were both the clinical symptoms of stiff-person syndrome and cerebellar ataxia. In western blot analysis her serum reacted with 65-kDa proteins from rat cerebellum, cerebral cortex, and spinal cord. Autoantibodies to GAD may cause functional impairment of gamma-aminobutyric acid (GABA) neurons in the spinal cord as well as in the cerebellum.|Autoantibodies/*blood[MESH]|Blotting, Western[MESH]|Cerebellar Ataxia/*complications/diagnosis/enzymology/immunology[MESH]|Diabetes Mellitus, Type 1/*complications/enzymology/immunology[MESH]|Electromyography[MESH]|Female[MESH]|Glutamate Decarboxylase/*immunology[MESH]|Humans[MESH]|Magnetic Resonance Imaging[MESH]|Middle Aged[MESH]|Stiff-Person Syndrome/*complications/diagnosis/enzymology/immunology[MESH] |