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Switching and signaling at the telomere Blackburn EHCell 2001[Sep]; 106 (6): 661-73This review describes the structure of telomeres, the protective DNA-protein complexes at eukaryotic chromosomal ends, and several molecular mechanisms involved in telomere functions. Also discussed are cellular responses to compromising the functions of telomeres and of telomerase, which synthesizes telomeric DNA.|Animals[MESH]|DNA Replication[MESH]|DNA-Binding Proteins/chemistry/metabolism[MESH]|Humans[MESH]|Models, Genetic[MESH]|Saccharomyces cerevisiae/genetics[MESH]|Signal Transduction[MESH]|Telomerase/*metabolism[MESH]|Telomere/*physiology/*ultrastructure[MESH] |