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lüll Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types Dumoutier L; Leemans C; Lejeune D; Kotenko SV; Renauld JCJ Immunol 2001[Oct]; 167 (7): 3545-9IL-10-related cytokines include IL-20 and IL-22, which induce, respectively, keratinocyte proliferation and acute phase production by hepatocytes, as well as IL-19, melanoma differentiation-associated gene 7, and AK155, three cytokines for which no activity nor receptor complex has been described thus far. Here, we show that mda-7 and IL-19 bind to the previously described IL-20R complex, composed by cytokine receptor family 2-8/IL-20Ralpha and DIRS1/IL-20Rbeta (type I IL-20R). In addition, mda-7 and IL-20, but not IL-19, bind to another receptor complex, composed by IL-22R and DIRS1/IL20Rbeta (type II IL-20R). In both cases, binding of the ligands results in STAT3 phosphorylation and activation of a minimal promoter including STAT-binding sites. Taken together, these results demonstrate that: 1) IL-20 induces STAT activation through IL-20R complexes of two types; 2) mda-7 and IL-20 redundantly signal through both complexes; and 3) IL-19 signals only through the type I IL-20R complex.|*Receptors, Cell Surface[MESH]|Carrier Proteins/metabolism[MESH]|Cell Line[MESH]|DNA-Binding Proteins/*metabolism[MESH]|Genes, Reporter[MESH]|Genes, Tumor Suppressor[MESH]|Growth Substances/*pharmacology[MESH]|Humans[MESH]|Interleukin-10/*pharmacology[MESH]|Interleukin-22[MESH]|Interleukins/*pharmacology[MESH]|Macromolecular Substances[MESH]|Models, Biological[MESH]|Receptors, Interleukin/genetics/*metabolism[MESH]|STAT3 Transcription Factor[MESH]|Signal Transduction[MESH]|Trans-Activators/*metabolism[MESH]|Transcriptional Activation[MESH]|Transfection[MESH] |