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  • Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types
  • Dumoutier L; Leemans C; Lejeune D; Kotenko SV; Renauld JC
  • J Immunol 2001[Oct]; 167 (7): 3545-9
  • IL-10-related cytokines include IL-20 and IL-22, which induce, respectively, keratinocyte proliferation and acute phase production by hepatocytes, as well as IL-19, melanoma differentiation-associated gene 7, and AK155, three cytokines for which no activity nor receptor complex has been described thus far. Here, we show that mda-7 and IL-19 bind to the previously described IL-20R complex, composed by cytokine receptor family 2-8/IL-20Ralpha and DIRS1/IL-20Rbeta (type I IL-20R). In addition, mda-7 and IL-20, but not IL-19, bind to another receptor complex, composed by IL-22R and DIRS1/IL20Rbeta (type II IL-20R). In both cases, binding of the ligands results in STAT3 phosphorylation and activation of a minimal promoter including STAT-binding sites. Taken together, these results demonstrate that: 1) IL-20 induces STAT activation through IL-20R complexes of two types; 2) mda-7 and IL-20 redundantly signal through both complexes; and 3) IL-19 signals only through the type I IL-20R complex.
  • |*Receptors, Cell Surface[MESH]
  • |Carrier Proteins/metabolism[MESH]
  • |Cell Line[MESH]
  • |DNA-Binding Proteins/*metabolism[MESH]
  • |Genes, Reporter[MESH]
  • |Genes, Tumor Suppressor[MESH]
  • |Growth Substances/*pharmacology[MESH]
  • |Humans[MESH]
  • |Interleukin-10/*pharmacology[MESH]
  • |Interleukins/*pharmacology[MESH]
  • |Macromolecular Substances[MESH]
  • |Models, Biological[MESH]
  • |Receptors, Interleukin/genetics/*metabolism[MESH]
  • |STAT3 Transcription Factor[MESH]
  • |Signal Transduction[MESH]
  • |Trans-Activators/*metabolism[MESH]
  • |Transcriptional Activation[MESH]
  • |Transfection[MESH]





  • *{{pmid11564763}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=11564763 Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types ]</b> J Immunol 2001; 167(7) ; 3545-9 Dumoutier L; Leemans C; Lejeune D; Kotenko SV; Renauld JC

        *11564763*

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    J Immunol

    3545 7.167 2001