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English Wikipedia
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Pharmacokinetics of levetiracetam Radtke RAEpilepsia 2001[]; 42 Suppl 4 (ä): 24-7Major considerations in the acceptance and impact of new antiepileptic drugs include their pharmacokinetics and their potential for interaction with other drugs. The pharmacokinetics of levetiracetam, a newly approved add-on antiepileptic agent for partial-onset seizures in adults, has been evaluated in 27 phase I and II studies. Consistent findings in these studies include rapid and complete oral absorption, linear dose kinetics, a minimal degree of protein binding, and predominantly renal excretion. Because of the lack of hepatic metabolism and low protein binding, the risk of interaction with other drugs is considered low.|Administration, Oral[MESH]|Adult[MESH]|Age Factors[MESH]|Aged[MESH]|Anticonvulsants/metabolism/*pharmacokinetics/therapeutic use[MESH]|Biological Availability[MESH]|Child[MESH]|Clinical Trials as Topic[MESH]|Drug Administration Schedule[MESH]|Drug Interactions[MESH]|Drug Therapy, Combination[MESH]|Epilepsy/*drug therapy/metabolism[MESH]|Half-Life[MESH]|Humans[MESH]|Levetiracetam[MESH]|Piracetam/*analogs & derivatives/metabolism/*pharmacokinetics/therapeutic use[MESH] |
