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lüll The neuropeptide pituitary adenylate cyclase-activating polypeptide and islet function Filipsson K; Kvist-Reimer M; Ahren BDiabetes 2001[Sep]; 50 (9): 1959-69The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is ubiquitously distributed in both the central and peripheral nervous systems and exerts a variety of effects. PACAP is a neuropeptide in pancreatic islets, where it has been suggested as a parasympathetic and sensory neurotransmitter. PACAP stimulates insulin secretion in a glucose-dependent manner, by an effect executed mainly through augmenting the formation of cAMP and stimulating the uptake of calcium. Accumulating evidence in animal studies points to a physiological importance of PACAP in the regulation of the insulin response to feeding. This review summarizes the current knowledge of islet actions and mechanisms and the function of PACAP.|Animals[MESH]|Hormones/metabolism[MESH]|Humans[MESH]|Islets of Langerhans/*physiology[MESH]|Neuropeptides/*physiology[MESH]|Pituitary Adenylate Cyclase-Activating Polypeptide[MESH]|Signal Transduction[MESH] |