Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Molecular physiology of oxygen-sensitive potassium channels Patel AJ; Honore EEur Respir J 2001[Jul]; 18 (1): 221-7Physiological adaptation to acute hypoxia involves oxygen-sensing by a variety of specialized cells including carotid body type I cells, pulmonary neuroepithelial body cells, pulmonary artery myocytes and foetal adrenomedullary chromaffin cells. Hypoxia induces depolarization by closing a specific set of potassium channels and triggers cellular responses. Molecular biology strategies have recently allowed the identification of the K+ channel subunits expressed in these specialized cells. Several voltage-gated K+ channel subunits comprising six transmembrane segments and a single pore domain (Kv1.2, Kv1.5, Kv2.1, Kv3.1, Kv3.3, Kv4.2 and Kv9.3) are reversibly blocked by hypoxia when expressed in heterologous expression systems. Additionally, the background K+ channel subunit TASK-1, which comprises four transmembrane segments and two pore domains, is also involved in both oxygen- and acid-sensing in peripheral chemoreceptors. Progress is currently being made to identify the oxygen sensors. Regulatory beta subunits may play an important role in the modulation of Kv channel subunits by oxygen.|*Nerve Tissue Proteins[MESH]|*Potassium Channels, Tandem Pore Domain[MESH]|Adaptation, Physiological/*genetics[MESH]|Animals[MESH]|Cell Hypoxia/*genetics[MESH]|Chemoreceptor Cells/*physiopathology[MESH]|Gene Expression Regulation/physiology[MESH]|Humans[MESH]|Hypoxia/genetics/*physiopathology[MESH]|Oxygen/physiology[MESH]|Potassium Channels, Voltage-Gated/*genetics[MESH]|Potassium Channels/*genetics[MESH]|Shal Potassium Channels[MESH] |