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lüll Sotalol: the mechanism of its antiarrhythmic-defibrillating effect Manoach M; Tribulova NCardiovasc Drug Rev 2001[Sum]; 19 (2): 172-82This minireview deals with the role of intercellular communication and synchronization in the initiation and maintenance of ventricular fibrillation. It is proposed that myocardial cell junctions might represent a therapeutic substrate for the prevention of this fatal arrhythmia. This hypothesis is supported by the results of recent experimental studies involving elucidation of the mechanism of antiarrhythmic-defibrillating effects of sotalol. Enhancement of intercellular communication and myocardial synchronization are thought to play critical role in the mechanism of action of this drug.|Adrenergic beta-Antagonists/*pharmacology/therapeutic use[MESH]|Animals[MESH]|Anti-Arrhythmia Agents/*pharmacology/therapeutic use[MESH]|Cytoprotection/drug effects[MESH]|Heart Conduction System/drug effects/physiopathology[MESH]|Humans[MESH]|Myocardium/cytology[MESH]|Sotalol/*pharmacology[MESH]|Ventricular Fibrillation/drug therapy/*prevention & control[MESH] |